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10 , 614288 (2020) M.J

Together, researchers combine them to examine potential complementary mechanisms in preclinical model systems

Interestingly, preclinical models have shown that curcumin can decrease the expression of Th1 cytokines (IL-12, IFN-gamma, TNF-alpha, IL-1) and increase the expression of Th2 cytokines (IL-4 and IL-10) in colon mucosa, promoting a shift from Th1 to Th2 [510]

Therefore, how to reasonably integrate various research findings and balance the differences under different experimental conditions is key to promoting the clinical application of silybin