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Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis

Many previous studies in experimental and clinical settings have demonstrated decreases in mitochondrial mass, alterations in mitochondrial morphology, reductions in oxidative capacity, and decreases in mitophagy (i.e., the ability to remove dysfunctional mitochondria) associated with aging and diseases, including glaucoma (Chistiakov, 2014