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During the pre-diabetes stage, BB rats that are diabetes prone have increased intestinal permeability, altered tight junction proteins (specifically claudin 7), increased gut infiltration by neutrophils and decreased numbers of gut natural killer cells in comparison to BB rats which were diabetes resistant [168, 178]

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In one study, ALS mice given a butyrate-producing bacterial cocktail showed delayed symptom onset and reduced neuroinflammation [217]

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1 The key features of PH include excessive proliferation of pulmonary artery smooth muscle cells (PASMCs), increased extracellular matrix deposition, and inflammatory factor accumulation in the pulmonary vascular wall, all contributing to elevated pulmonary vascular resistance