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Consequently, we observed that this beneficial effect, after direct injury (permanent ligation) applied to one or two major vessels, could instantly oppose more general damage (maintained intra-abdominal hypertension, either high (grade III) or very high (grade IV)), as all blood vessels which can be compressed with increased intra-abdominal pressure

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These changes can influence the behavior of mechanosensitive proteins such as integrins, which mediate the cells response to mechanical stress

Estradiol is the main form of estrogen used in hormone replacement therapy (HRT, now commonly referred to as menopause hormone therapy, or MHT), as its the most potent form of estrogen available

Richardson et al., 2020)