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Poly ADP-ribosylation, also known as PARylation, is a type of PTM in which polymers of ADP-ribose are covalently attached to target proteins by PAR polymerase (PARP) enzymes, resulting in a dramatic electrostatic change of the acceptor protein surface 128

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Further, we thank the laboratories of John Cleveland, Elsa Flores, Bob Gillies, Ana Gomes, and Vince Luca for access to their equipment in support out this study

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Contemporary CF research has consequently shifted toward MS-centric methodologies offering superior sensitivity, throughput, and capabilities for identifying specific post-translational modifications essential for comprehensive oxidative stress analysis