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334 Interfering RNA or antisense RNAbased therapy constitutes another method to suppress the Wnt/-catenin pathway, showing suppressive effect to HCC in vitro 335,336 and in mouse models

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To investigate this potential release, NP4 was incubated with phosphate-buffered saline (PBS) or PBS containing H 2 O 2 as a model for ROS inside the cancer cells and the release monitored by ICP-MS

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GPx isoenzymes are all antioxidant enzymes that reduce potentially damaging reactive oxygen species (ROS), such as hydrogen peroxide and lipid hydroperoxides, to harmless products like water and alcohols by coupling their reduction with the oxidation of glutathione (Figure 2a )

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