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Description

Clinical analysis of liver function abnormality in children

Under normal physiological conditions, activation of the Keap1-NRF2 signaling pathway promotes the activation of System Xc - and the expression of GPX4 and accelerates cysteine glutamate transport, thereby clearing accumulated lipid peroxidation and inhibiting ferroptosis (86)

Kutsche, H

a , Motif-enrichment results from published datasets in cells after ligand stimulation ( a ), oncogenic mutation ( b ), or targeted inhibition ( c ) of Tyr kinases