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BMJ open 12 (3), e056545

Disruption of lung iron homeostasis appears to be involved in several lung diseases and we therefore looked for evidence of ferritinophagy, which describes a form of selective autophagy characterised by degradation of intracellular ferritin mediated by nuclear receptor coactivator 4 (NCOA4), which increases intracellular iron levels leading to accumulation of lipid ROS and ultimately cell death [52]

And yet the stomach functions for decades without problems

Of importance, additional work is required to elucidate the mechanisms of lipid peroxides triggering necroptosis and upstream kinases involved in this process