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The use of a multiplexing approach with a robust CRISPR/Cas9 array having single or multiple sgRNAs or RNPs targeting conserved sequences of target genes and protoplast-mediated transformation could be deployed for precision editing

Moreover, MDA promotes the aberrant aggregation of -syn by modifying its 15 lysine sites, thereby initiating Lewy body formation and driving the pathological process of PD (90)

Lindh JD, Lundgren S, Holm L, Alfredsson L, Rane A

This allows it to pass through the intestinal wall and enter the bloodstream more effectively

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Inhibition of bile acid (BA) transporters is a potential therapeutic option to treat NASH by restoring lipid homeostasis and reducing inflammatory burden