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A May 2025 study in Molecular Therapy from the INc-UAB showed that gene therapy increasing secreted klotho (s-KL) in mice extended lifespan by 15-20% while improving muscle, bone, and cognitive health at 24 months of age (equivalent to ~70 human years)

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Retatrutide vs Semaglutide vs Tirzepatide Retatrutide is commonly compared with Semaglutide and Tirzepatide in receptor pathway research because each compound is associated with a different receptor profile

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But if people ask me, Would you take it? I would say no, citing worries about the long-term effects on things like tumor growth and whether it can enhance already proven levers like good nutrition, sleep, and rehab