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Starting at a lower dose and increasing gradually helps assess tolerance and minimize any initial digestive discomfort

On the other hand, decrease in glutathione is one of the earliest biochemical changes in PD and incidental Lewy body disease [109]

In neuroinflammatory models, BHBA promotes microglia polarization toward M2, which exerts anti-inflammatory effects and prevents depressive-like behaviors (187)

Two weeks of treatment with lion's mane mycelia reduced immobility time in stress tests and activated BDNF pathways while blocking NF-B signals in mice [8]

doi: 10.1038/s41577-020-0285-6 45 MakTWGrusdatMDuncanGSDostertCNonnenmacherYCoxMet al

Immunohistochemical analysis of cerebellar tissue further demonstrated an upregulation of pro-inflammatory markers, including inducible iNOS, and elevated tau expression, indicating ongoing oxidative and inflammatory injury