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2e), dHTC1 showed weak and nonspecific (that is, unsaturable) binding and an estimated K D of nearly 50 M (Fig

Nevertheless, despite these advances, effective clinical translation remains elusive, and no therapies specifically targeting ferroptosis have yet been approved for cardiovascular indications

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Thereby, deregulation of lipid metabolism may initiate a positive feedback loop that serves to maintain senescent arrest, independent of the persistence of DNA damage or other initiating stresses