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Walls, E.A

It willingly gives up an electron to neutralize these dangerous free radicals before they can cause structural damage to the cell

Not only that, the comparative analysis of the therapeutic effects between AS-IV and anti-PF drugs, such as pirfenidone and nintedanib and the dose-response relationship between the dosage and anti-PF effect of AS-IV remain unclear

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In this protective role, ATF4 drives the expression of the chaperone heat shock protein family A (Hsp70) member 5 (HSPA5), which in turn stabilizes and enhances the activity of GPX4, thereby inhibiting ferroptotic cell death ( In ferroptosis resistant melanoma cells, CHAC1 was shown to be upregulated by NRF2 independent from ER stress signaling alongside the Aldo-Keto Reductase Family 1 Member C1 (AKR1C1) capable of degrading lipid radicals ( CHAC1 , most melanoma cell lines appear to be resistant against ferroptosis

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