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Malonyl-CoA accumulates in the absence of fatty acids in these cells in an ACC-dependent manner (Supplemental Figure 4D), and labeling paralleled that of acetyl-CoA, suggesting that glucose-derived carbon may feed into an extramitochondrial acetyl-CoA pool in these cells (Figure 5C)

Hepatol (Baltimore Md) (2016) 63(1):17384

Agricultural Research Service

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The overweight and obese status in diabetic participants may be implicated to cause an impaired cell response to insulin