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After a 10 minute rest period, images were recorded before and 4 minutes after administration of a sublingual nitroglycerin tablet (0.4 mg)

European Heart J 2023

Thus since its inception, the somatomedin hypothesis has evolved to describe a more complex interplay between GH and IGF-1 (commonly referred to as the GH/IGF-1 axis) including negative feedback mechanisms where IGF-1 inhibits further GH production (Figure 2) [145]

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