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Even without genetic variations, constant stress, like from toxins or environmental causes, also affects the activity of genes and, therefore, the enzymes

Also, the trough concentration was not significantly increased at Day 22 compared with Day 1 at all doses

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You should not take Imigran if you: Are allergic to sumatriptan Have heart disease such as angina or a history of heart attack Have circulation problems in your legs (peripheral vascular disease) Have had a stroke or transient ischaemic attack (TIA) Have uncontrolled high blood pressure Have severe liver disease Are taking medicines containing ergotamine or similar medicines such as methysergide Are taking other triptans (5-HT1 receptor agonists) Are taking MAOIs or have taken them in the last 2 weeks If you are pregnant, speak to a healthcare professional before using Imigran