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Estrogen impacts mitochondrial function through increasing oxidative phosphorylation, while at the same time decreasing mitochondrial superoxide production (Duckles et al., 2006

doi: 10.1523/JNEUROSCI.2111-04.2004

However, amidst these challenges, there are promising opportunities [101, 127]

Ethanol activates microglia, the resident immune cells in the brain, leading to chronic neuroinflammation characterized by the release of pro-inflammatory cytokines such as TNF- and IL-1