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doi: 10.1158/1535-7163.MCT-20-0390 385 JiangYDengQZhaoHXieMChenLYinFet al

Invest Ophthalmol Vis Sci 48, 31613177

The classical cytosolic/mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered

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There are numerous articles demonstrating that cereblon-based PROTACs can rapidly, potently and highly selectively degrade, both in vitro and in vivo, a huge number of different proteins associated with the development of various diseases, including cancer, neurodegenerative diseases, immune diseases, cardiovascular diseases and viral infections 33,34

Its an IV therapy given every two weeks and works wonders for patients with frequent flare-ups and tophi