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Optimization of the synthetic routes resulted in substantial improvement in the yields, as DYn-1 was synthesized in 2 steps (85% overall yield) and DYn-2 was synthesized in one step (96% yield)

Young-onset Parkinsons disease is a kind of Parkinsons disease that appears before the age of 20

Penile palpation did not detect any nodules, and ultrasound no longer showed any plaque

After treatment with GLY, the levels of GPX4, Nrf2 and HO-1 were significantly increased, while the protein level of HMGB1 in the model group was significantly decreased

The Bcl-2 family proteins regulate apoptosis by altering mitochondrial membrane permeabilization which leads to the release of apoptogenic factors such as cytochrome c , procaspases, and apoptosis inducing factor (AIF)

Absolute quantification of pyroglutamic acid Targeted quantification of PGA by LC-MS was performed with a specific protocol and performed according to [53,54,55] at the Swedish Metabolomics Center in Ume, Sweden