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Often, biological networks combined with Genome-Wide Association Studies (GWAS) are the most commonly employed sources of information for drug repurposing, as GWAS studies are intended to impartially link controlled factors to genetic or transcriptomic alterations in human subjects with no specific emphasis on a single gene or fixed set of genes 25,26

In addition, more detailed studies to better characterize the abnormalities in energy metabolism in patients with ALS and ALS models are necessary to develop metabolically targeted effective therapies that can slow the progression of the disease and prolong life for patients with ALS

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[Comparison of the therapeutic efficacity of 2 induction protocols in acute myeloid leukemia using exact quantification of bone marrow cellularity]

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JAMA 1992;268:3224-3227