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It has been observed that the apoptotic process in paclitaxel induced-painful neuropathy is due to the permeability transition pore opening, with the consequent cytochrome c release and Ca 2+ homeostasis dysregulation (Areti et al., in vivo could also reverse or attenuate the above-mentioned symptoms, but with deleterious effects on motor coordination in the case of complex I inhibition at 3 and 24 h after paclitaxel administration

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R 2 , R 3 , R 4 , and R 5 are independently selected from the group consisting of: H, C 1-4 alkyl, halogen-substituted C 1-4 alkyl, NR 9 R 10 , and CN

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Second Messenger Cascades Metabotropic receptors can alter protein function in the cell through second messenger cascades