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Stress can increase acid production and slow digestion, which may worsen symptoms

Are nutrient and protein oxidation inherently incompatible due to redox limitations

These perturbations lead to the release of mtDAMPs, rewire immune cell metabolism toward pro-inflammatory or immunosuppressive phenotypes, and impair the bioenergetic capacity needed for effective host defense and tissue repair ( Figure 2 )

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1 The exportin-1 inhibitor selinexor was evaluated in the phase 3 BOSTON study of selinexor, bortezomib, and dexamethasone therapy administered once weekly versus twice weekly doublet therapy with bortezomib and dexamethasone