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This promoted the translocation of Bcl-2 to the outer mitochondrial membrane, where it interacted with voltage-dependent anion channel 1, inhibiting mitochondrial permeability transition pore (mPTP) opening

The results at the short-term time point (1 h) suggested that uric acid may induce oxidative stress, leading to protein carbonylation in VSMCs and a high reactivity of uric acid with cellular proteins indicating that it may rapidly cause oxidative modifications

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The same study also tested whether glutathione would be toxic to animal cells, especially at elevated levels

Adding less water than the label calls for is the opposite and more dangerous problem it over-concentrates the solution and can cause an inadvertent overdose