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doi: 10.1155/MI/2006/36192 92 JosephL.MercieccaT.ForestierC.BalestrinoD.MiquelS

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Inflammatory mediators (such as cytokines and interleukins) activate NF-B, which inhibits the induction of P450 isoforms (as CYP3A4, CYP2B6, and CYP2C9) by the nuclear receptor PXR (Pelkonen et al., 2008)

10.1016/0959-8049(96)00051-2 Eur

This progressive neurodegenerative disease leads to eventual death due to paralysis and respiratory failure

MLKL-induced SMC death leads to release of DAMPs and promotes PMN activation To show that MLKL-induced necroptotic SMC death is a crucial first step in the activation of PMN and subsequent AAA development, we generated two human aortic smooth muscle cell (hSMC) lines by transfecting Tet-On 3 G inducible expression constructs encoding for full-length human MLKL (F-hMLKL) and N domain of human MLKL (ND-hMLKL) (aa 1-182) (Fig