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This family of compounds represents a new class of drugs with lead candidates that are orally active, penetrate the BBB sufficiently to reach therapeutic concentrations, and reverse memory deficits seen in animal models of dementia

Front Immunol 11:504077 Scherlie R (2020) Nasal formulations for drug administration and characterization of nasal preparations in drug delivery

Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators

10.1172/JCI38940 15 ChangC.WorleyB