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For example, anergy in T cells is characterized by a lack of cytokine production (e.g., IL-2)

Interestingly, TMAO affects bone homeostasis [13]

They also contain zinc and copper polycarboxylic acids (trace metals that are important co-factors for collagen production and regulation)

Artificial intelligence (AI)-assisted spatial metabolic imaging and response modeling have been employed to dynamically predict drug responsiveness across distinct tumor regions, providing a robust foundation for the development of metabolism-guided combination strategies [132]

doi: 10.1016/j.idairyj.2019.03.012 61