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When multiple circuitries break down, patients come close to a point-of-no-return in which health appears definitely lost and therapeutic interventions appear likely impossible (Lpez-Otn and Kroemer, 2021)

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Capsaicin works by depleting substance P, a neuropeptide involved in transmitting pain signals, leading to the desensitization of pain fibers

Gelhaye, C

Bodo C Melnik and Gerd Schmitz contributed equally to this work