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Consequently, they are gaining prominence as novel participants, given that increased platelet aggregation constitutes a crucial risk factor for thrombosis, heart attacks, and strokes (177)

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doi: 10.3389/fimmu.2023.1092651 25 Izquierdo LafuenteBVerboomTCoenraadsSUmmelsRBitterWSpeerA

Development from Melanotan II The development of PT-141 emerged from research on Melanotan II (MT-2), a peptide originally synthesized for photoprotection and skin tanning through melanocortin-1 receptor (MC1R) activation

3.3 Risk assessment of bias in included studies Assessment of the 10 included trials using RoB 2.0 (Figure 2) revealed an overall risk of bias categorized as some concerns. Key methodological issues included inadequate randomization and allocation concealment, unclear blinding of outcome assessors, and potential selective reporting due to discrepancies between the registration protocol and the final published results

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