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It induces cell apoptosis by destroying mitochondrial membrane potential and inducing DNA fragmentation

Signaling pathways and molecular process of natural polyphenols in the amelioration of inflammatory bowel disease: a privileged scaffold in new drug discovery

NMR Biomed 23:8087

[Pyridin, the hydrogen-transferring component of the fermentation enzymes (pyridine nucleotide)]

This suggests that no other SAM sites exist in the filament beyond S2, but it is also possible that mutation of these residues could alter another putative cryptic SAM binding site indirectly