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10.1093/eurheartj/ehx342 17

LL-37: A host defense peptide with clinical potential

Materials and methods Reagents LPS (from Escherichia Coli 0111: B4) for the in vivo study was purchased from Sigma

Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes

In addition to glutathione, this complex includes bioavailable B vitamins to optimize energy levels and milk thistle extract to support liver health and proper bile flow

Activation of TRPV1 restored GPX4 levels, reduced lipid peroxidation, and improved cartilage integrity in both IL-1treated chondrocytes and OA mouse models ( These findings highlight the importance of considering cellular heterogeneity in ferroptosis regulation and suggest that targeting ferroptosis in a subpopulation-specific manner may enhance therapeutic precision in OA