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Materials and methods Synthesis of MOF-199 and A@MOF To provide a clear overview of the fabrication process, a schematic diagram illustrating the step-by-step preparation of MOF-199, A@MOF, and A@MMOF, as well as the mechanistic role of each component, is shown in Fig

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These were generally mild, in the range of 2-4 beats per minute at lower doses and up to 6-8 BPM at 12mg, and did not produce clinical symptoms in most participants

These combinations target complementary pathways and may provide synergistic metabolic benefits