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Description

Elderly cartilage essentially non-healing for significant injuries

[27] demonstrated that blood orange phenotype results from the insertion of an LTR retrotransposon in the promoter region of the Ruby gene (which encodes for a MYB transcription factor) and that this gene is specifically activated in fruit in a cold-dependent manner

In vitro cellular uptake assays demonstrated that the SS31 peptide selectively targets macrophage mitochondria, downregulating CD36 and lectin-like oxidized LDLR-1 expression, thereby reducing ROS production, restoring mitochondrial function, and limiting cholesterol influx