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Perioperative implications were evaluated with emphasis on orthopaedic surgical risk domains relevant to total joint arthroplasty (TJA), including wound complications, hematoma formation, immune modulation, infection susceptibility, heterotopic ossification, and implant fixation considerations

Alcohol use and burden for 195 countries and territories, 19902016: A systematic analysis for the Global Burden of Disease Study 2016

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Development of auto-antibodies Some cobalamin preparations in rare cases can stimulate an allergenic response where there is development of antibodies to the cobalmin injected

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Since the body does not manufacture it, the only way to get it is through diet and/or supplementation