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Significant fatigue that interferes with daily activities

Genetic modifiers such as the presence of an E4 allele of apolipoprotein E (ApoE) or polymorphisms in the methylenetetrahydrofolate reductase gene ( MTHFR ) may contribute to age of WD onset but these studies await confirmation in larger, independent populations

Disclosures Peer reviewer affiliations and disclosures pertain to the time of the review

[3] Soerjomataram I, Bray F

The mechanisms of action associating diet with health outcomes are complex, multifaceted, interacting, and not restricted to any one biological pathway

While many autoimmune disorders present with vague or overlapping symptoms, certain patient presentations raise red flags for underlying mast celldriven neuroinflammation and warrant a deeper investigative approach