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Although rare in developed countries, pellagra remains endemic in poorer regions, with risk factors including low socioeconomic status, alcoholism, anorexia nervosa, cancer, and malabsorptive disorders, such as Crohns disease, as well as the use of some specific medications such as immunosuppressive and anti-tuberculosis drugs (54)

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Notably, high concentrations of zinc are also found in the retina and choroid of the eye 23,24

doi: 10.3390/cimb47080618, 38

Glycolysis regulates NLRP3 inflammasome activation in macrophages (61)