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It is reported that ROS is a common upstream mechanism in the activation process of NLRP3 inflammasome

Mucosal Immunol 9: 322335 Fadok VA, Bratton DL, Konowal A, Freed PW, Westcott JY, Henson PM (1998) Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGFbeta, PGE2, and PAF

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Moreover, a reduced data set ( n = 139) was further used to verify if the previously observed repetitive shifts in relative TW CCS N2, meas between parent drugs (or precursors) and their metabolites were biotransformation-specific