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In this context, Du et al., noted loss of tissue resident macrophages in colon biopsies from patients with ulcerative colitis, that was accompanied by decreased superoxide dismutase 2 expression (an important antioxidant) in the macrophages [3]

Premature graying is often linked to hypothyroidism, heavy metal accumulation, drug use, excessive free radicals, and nutritional deficiencies

Additionally, FTMGL not only inhibits the pigment deposition through antioxidant activity, but also reduces MITF expression by modulating p38 and JNK in the cAMP-PI3K/Akt and MAPK signaling pathway, thereby inhibiting melanin synthesis in melanoma cells (Pudlarz et al., 2020) (Figure 2)

This includes recognising signs of a flare-up and facilitating appropriate referral to primary or secondary care services for review

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Green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG): a time for a new player in the treatment of respiratory diseases