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Empirical evidence indicates that the in vitro interaction of the H9N2 virus with chicken erythrocytes induces the expression of complement-related genes, including C1s , C1q , C2 , C3 , C3AR1 , C4 , C4A , C5 , C5AR1 , C7 , CD93 , and CFD within these cells

However, targeting epigenetic machinery likely has a broad impact on gene expression, and more studies are needed to define their specific effects on tumor metabolism

PMID 8099447

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With respect to the cost criterion, to identify potential cases representing patients who may be eligible for the Ceribell Delirium Monitor, the applicant searched the FY 2021 MedPAR file for claims with charges in the revenue codes 020X (Intensive Care Unit) and 021X (Coronary Care Unit) for patients age 65 or older, based on the expected FDA label and because the technology can be utilized for any patient in intensive or critical care units

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