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However, clinical translation faces several challenges: difficulties in large-scale production of complex nanostructures requiring precise control of layered compositions (118), systemic oxidative damage (e.g., hepatotoxicity) caused by free iron ions (137), long-term retention issues of certain metal nanoparticles (138), potential complement system activation or inflammatory responses triggered by nanoparticles (139) and limited delivery efficiency due to tumor stromal barriers and immunosuppressive TME (140)

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Without adequate Vitamin C (and by extension, glutathione), the enzymatic reactions needed to form stable collagen triple-helix structures are impaired

Aging Cell 23 (8), e14184

These data suggest that the RFK-dependent biosynthesis of FAD from vitamin B2 has an important role in enabling cancer cells to suppress ferroptosis