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Ferritin light chain interacts with PEN-2 and affects gamma-secretase activity

Precursor-directed immune-mediated anemia Dogs and cats with precursor-directed immune-mediated anemia (PIMA, also called non-regenerative immune-mediated anemia) usually present with severe normocytic normochromic anemia (Hcts, 20% cells with bound IgG) in low numbers of dogs (5/17, 29%) and a similar number of precursors were expressing phosphatidylserine (20-80% of cells)

In one single-center trial of 72 subjects using a controlled-adverse-environment model, the T4 eye drop did not meet its co-primary endpoints (ocular discomfort and inferior corneal staining) at the primary time point, but it did produce statistically significant improvements on several secondary endpoints, including central and superior corneal staining, with no adverse events reported

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worsens with overhead tasks or carrying heavy bags

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