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doi: 10.15252/embr.202153086 14 ChakrabortyS.RahateK.KumarC.Idicula-ThomasS

Such metabolic rewiring towards increased aerobic glycolysis also formed the basis for -glucan-induced trained immunity of monocytes and was associated with epigenetic histone modifications and increased expression of genes involved in glycolysis triggered by the AKT-mTOR-HIF1 pathway (Sohrabi et al., 2018

References 1 SpontonCHGKajimuraS

This pathway serves as an alternative elimination route, but the short supply of glycine in the obese state may impair glycine conjugation and compromise this detoxification system

This will keep you from using the wrong one

Table 2 shows the computed AIC and BIC values, illustrating that the reduced model returns a much higher score than the triad and comproportionation models