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Trials typically incorporate biomarker endpoints such as ER/ER ratios, aromatase activity, plasma isoflavone or polyphenol concentrations, immune cell phenotyping, cytokine panels, oxidative stress markers and microbiome profile which are used to provide mechanistic read-outs of supplement activity and to inform patient stratification approaches (231)

(2016), LAT1-targeted nanoparticles reduced the plasma membrane expression of the transporter in HeLa cells when measured 1 h after exposure (82)

This keeps the two actives in separate applications entirely and is often the best-tolerated structure

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