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There are two main pathways for cysteine catabolism: one is via its enzymatic breakdown to produce H 2 S and organic intermediates that will serve as carbon sources, and the second is via oxidative metabolism through cysteine dioxygenase (CDO)

Nuclei were stained by incubation with DAPI

Interplay between oxidant species and energy metabolism

This observation suggests that metabolic dysregulation in SLE extends to the memory B cell compartment and may contribute to persistent autoimmune responses

Results Cell Viability Assay Cell viability tests were performed on HaCaT keratinocytes cells with the treatment of GHK, CuCl 2 and Cu(OAc) 2 for 24, 48 and 72 h