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Mol Cancer 2011

47 , 8596 (2015b)

The Hordaland Homocysteine Study: A Community-Based Study of Homocysteine, Its Determinants, and Associations with Disease1. The Journal of Nutrition, vol

R Clinical implications of slow acetylation: Increased risk of isoniazid-induced hepatotoxicity and peripheral neuropathy (tuberculosis treatment) R Increased risk of sulfonamide hypersensitivity reactions R Increased risk of aromatic amine-related bladder cancer in occupational exposure settings (dye workers, rubber industry) R Drug-induced lupus from hydralazine and procainamide occurs almost exclusively in slow acetylators R Altered caffeine metabolism (slow acetylators clear caffeine more slowly via the NAT2 pathway) R NAT1 polymorphisms are less well characterized but the slow allele NAT1*14 has been associated with increased risk of cancers from dietary aromatic amines

The proposed mechanism for the cause of favism is that these new compounds then undergo redox cycling and in the process deplete reduced glutathione, leading to the formation of free radicals and hydrogen peroxide that damage red blood cells in individuals deficient in G6PD

The number of osteoclasts within the femoral condyle was quantified using Tartrate-resistant acid phosphatase (TRAP) staining, performed in accordance with previously reported methods [32]