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BI2536 (HY-50698), MLN8237 (HY-10971) and ZM447439 (HY-10128) were all purchased from MedChemExpress

Considering its low cost, safety, and accessibility, zinc presents itself as a valuable intervention to support healthy aging and improve quality of life

There are many indications that LSECs can contribute to the secretion of IL-1, IL-6, TNF- and IL-18 during cellular injury or in response to inflammatory stimuli 54,55,56,57

Type 1 IGF receptor-immunoreactive cells were counted in the GCL and INL of the rats in all three groups in order to determine if the changes in immunoreactivity were significant