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Mitochondria act as oxygen sensors, altering cytoplasmic redox status by affecting mtROS production under hypoxia, which in turn regulates HPV mediators (e.g.,: ion channels and kinases) (Sommer et al., 2016)

This rapid stretching can cause damage to collagen and elastin fibres in the deeper layer of the skin

FAPI-04, published in 2018 by Lindner et al., showed slow excretion and high tumour accumulation, and was considered the best tracer for FAP-targeted radioligand therapy despite its short tumour retention time