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Journal of Pharmacology and Experimental Therapeutics, 270(1), 180-185

The strategies to address senescent cells and replenish exhausted stem cells during the aging process, as well as supplementing metabolic substances like NAD+, gene therapy, or epigenetic approaches to mitigate aging, are different because they aim to promote the repair of senescent cells rather than inducing their apoptosis (Covarrubias et al., 2020

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I'm old enough to remember when gene therapy was set back by about 10 years because a patient received gene therapy, which is now pretty common for certain diseases, and the patient died

Bottom line: Higher NAD+ = better energy, sharper cognition, and cellular longevity

The N-terminal residue (Ala) is on the left, and the C-terminal Gly on the right