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Furthermore, deposits of IgG, IgM, and complement were detected in the sciatic nerves of SOD1 G93A mice along with macrophage accumulation [144]

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noted reduced expression of the GHR in the kidneys of 5/6 nephrectomized animals, which was associated with elevated pro-inflammatory cytokines, suggesting that GH-insensitivity in uremia is a general phenomenon and not restricted to the liver and growth plates ( vide supra ) [174]

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Understanding selectivity helps clarify when AOD-9604 is the appropriate choice versus other interventions

Joeckel, L