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In one preclinical study, a D3G-rich blueberry extract significantly reduced blood glucose levels in diabetic mice, increased antioxidant SOD activity, and improved insulin sensitivity [107]

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The persistent hyperglycemia in diabetic patients leads to the massive deposition of AGEs in endothelial cells, glomerular basement membrane and podocytes, directly damaging the normal structure of the glomerulus, impairing filtration function, and leading to the production of proteinuria (Wu et al., 2021)