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Deferiprone (DFP), a commonly used iron chelating agent, demonstrates the ability to cross the blood-brain barrier (BBB) and transfer iron from DFP-Fe to TF for the treatment of serum iron overload

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It acted via non-competitive inhibition, binding to non-active sites and inducing structural rearrangements, with reduced -helical content and increased -sheet and random coil, thereby disrupting ACE function without active-site competition

The method according to claim 1 or 2, the use according to any one of claims 3-6, or the composition according to claim 7 or 8, wherein the Autism Spectrum Disorder (ASD) comprises syndromic autism, autism of known etiology, fragile X syndrome, PTEN macrocephaly syndrome, RETT syndrome, tuberous sclerosis complex, Timothy syndrome, or Joubert syndrome

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This model is also the first to characterise the exposure and effect of daily GH (Norditropin ) to be published, despite the product being available for many years